Analyzing a Simplified Geriatric Assessment in Older Patients with Diffuse Large B-Cell Lymphoma

The use of a simplified geriatric assessment (sGA) can be used as an objective tool to integrate into a prognostic score for elderly patients with diffuse large B-cell lymphoma (DLBCL), according to a study published in the Journal of Clinical Oncology.

In this prospective study, researchers analyzed 1,163 patients aged older than 64 years with DLBCL who underwent original geriatric assessment (age, Cumulative Illness Rating Scale for Geriatrics, activities of daily living, and instrumental activities of daily living) before treatment. Treatment choice was left to the physician’s discretion, the researchers noted. The primary end point was overall survival (OS).

According to the results, advanced age (>80 years) was an independent factor associated with OS. The researchers were able to develop a new sGA that classifies patients as fit (55%), unfit (28%), and frail (18%) with significantly different three-year OS of 75%, 58%, and 43%, respectively. The researchers further noted that sGA groups, International Prognostic Index, and hemoglobin levels were independent predictors of OS and were used to build the Elderly Prognostic Index (EPI).

The Elderly Project validates sGA as an objective tool to assess fitness status and defines the new EPI to predict OS of older patients with DLBCL,” the researchers concluded.