Self-reported poor sleep quality was associated with shorter survival in patients with
lung cancer, according to a study published in
Cancer Management and Research
Researchers retrospectively analyzed a cohort of 404 patients with lung cancer who
were treated at the Institute of Oncology in Israel between 2010 and 2018.
Participants self-reported sleep quality, distress, and pain via questionnaires that
were administered at their first clinic visit. Demographics, including sex, age,
histology, stage, smoking, and marital status were assessed via chart review.
Many patients experience poorer sleep quality
Most patients reported some level of distress and pain, and more than half (58.7%)
reported sleep abnormalities. Distress, pain, and poor-quality sleep were associated
with shorter survival, per univariate analysis. However, only sleep remained
associated with survival in multivariate analysis.
Patients who reported poor sleep quality had a median survival of 16 months
compared to 27 months among patients reporting good-quality sleep (hazard ratio,
1.83; 95% CI, 1.27- 2.65). Frequent waking at night was more closely associated
with survival than difficulty falling asleep.
“Further studies are required to comprehend whether poor sleep quality is directly
impacting survival or is a result of the cancer aggressiveness and patients’
conditions,” the researchers concluded.