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GVHD

Thymoglobulin Prevents Graft-Versus-Host Disease in Transplants from HLA-Matched Sibling Donors

While antithymocyte globulin (ATG) has proven effective in preventing chronic graft-versus-host disease (GVHD) after transplantations from HLA-unmatched donors, there are few studies that have...

CD34-Selected Stem Cell Boost for Poor Graft Function after Allogeneic Hematopoietic Stem Cell Transplantation

Researchers conducted a meta-analysis to evaluate CD34-selected stem cell boost (SCB) treatment in patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) and then...

Intravenous Vedolizumab for the Treatment of Steroid-Refractory Intestinal Acute Graft-Versus-Host Disease

In a recent phase IIa trial, Yngvar Fløisand, MD, PhD, and colleagues, aimed to evaluate the efficacy, tolerability, and safety of vedolizumab—an approved treatment...
Children Undergoing Thyroidectomy Have Better Outcomes at High-Volume Pediatric Surgery Centers

DNA-Repair Gene Variant Linked to Acute Graft-Versus-Host Disease in Pediatric Patients

Researchers co-led by C. R. S. Uppugunduri and P. Huezo-Diaz Curtis from the University of Geneva, discovered an association between DNA-repair gene variant MGMT...
hydrogel

Fecal Microbiota Transplantation in Severe, Steroid-Refractory GI GVHD

A phase I/II clinical trial conducted at the First Affiliated Hospital of Soochow University found that fecal microbiota transplantation (FMT) displayed promising results when...
contact lens

Investigating Corneal Perforation in Ocular Graft-Versus-Host Disease

A retrospective case series from four U.S. academic centers examined the disease course and histopathologic characteristics of corneal perforations in patients with ocular graft-versus-host...

Beta-Blockers and Reduced Risk of Graft-Versus-Host Disease Development

A study, published in Hematology/Oncology and Stem Cell Therapy, found that using beta-blockers appeared to reduce the risk of developing chronic graft-versus-host disease (cGVHD)...
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