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Myeloproliferative Neoplasms

Gene Variant Frequency May Predict VT Risk in Polycythemia Vera Patients

In patients with polycythemia vera (PV), arterial thrombosis (AT) and venous thrombosis (VT) events are common complications and are the leading causes of PV-related...
A New Approach to Treating Acute Lymphoblastic Leukemia

Incidence of Abnormal B-Lymphoblasts in MDS and MPN

According to Alexander Chan, MD, and colleagues from the Department of Pathology at the Memorial Sloan Kettering Cancer Center, driver gene events are frequent...
Hand with IV Drip Receiving Medical Treatment

Abnormal Signatures of Extracellular Vesicles in Polycythemia Vera

Polycythemia vera (PV) is subject to the chronic inflammation commonly observed in other myeloproliferative neoplasms. Recent data point to circulating microbes and microbial components...

Arsenic Trioxide and Chemotherapy Quality of Life Outcomes in Acute Promyelocytic Leukemia

In a follow-up to the randomized controlled trial APL0406, researchers compared long-term health-related quality of life of patients with acute promyelocytic leukemia (APL) who...

Entinostat Plus Clofarabine for Acute Lymphoblastic or Biphenotypic Leukemia

A phase I study tested low dose clofarabine with escalating doses of entinostat in adults with Philadelphia chromosome-negative, newly diagnosed (ND) or relapsed/refractory (R/R)...

Dociparstat Sodium With Azacitidine for Refractory Acute Myeloid Leukemia and Myelodysplastic Syndrome

In an a study published in Leukemia Research, researchers trialed the combination of dociparstat sodium (DSTAT) and azacitidine for patients with hypomethylating agent (HMA)...

Randomized Phase II Study of Imetelstat in Relapsed or Refractory Myelofibrosis

A study published in the Journal of Clinical Oncology found that therapy with two doses of imetelstat appears to have clinical benefits for both...
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