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Multiple Myeloma Knowledge Hub

Multiple Myeloma and Waldenström Macroglobulinemia Patients Have Impaired COVID-19 Vaccine Responsiveness

According to a poster presented at the 2021 ASH Annual Meeting by Andrew R. Branagan, MD, PhD, and colleagues, patients with myeloma and Waldenström...

Four-Drug Regimen of Dara-KRd Plus AHCT and Consolidation Induces MRD Negativity

According to findings presented at the 2021 ASH Annual Meeting, the combination of daratumumab, carfilzomib, lenalidomide, and dexamethasone (Dara-KRd), autologous hematopoietic cell transplantation (AHCT),...

Isatuximab Plus RVd Produces Better MRD Negativity Rates Than RVd Alone

The addition of isatuximab to lenalidomide, bortezomib, and dexamethasone (RVd) improved rates of measurable residual disease (MRD) negativity better than RVd alone in patients...

Results from the iStopMM Study Suggest MGUS Screening Enables Early Detection and Intervention

In the iStopMM (Iceland Screens, Treats, or Prevents Multiple Myeloma) study, researchers explored whether population-based screening for monoclonal gammopathy of undetermined significance (MGUS) could...

Enrollment of Black Americans in Pivotal Chimeric Antigen Receptor-T Cell Clinical Trials

Black Americans were severely under-represented in clinical trials that supported FDA approvals of chimeric antigen receptor (CAR)-T cell therapies in patients with multiple myeloma...
T cell attacking a cancer cell

Updated Results from CARTITUDE-1 Trial Show Continued Efficacy of Ciltacabtagene Autoleucel in Treating Relapsed/Refractory...

A study reported updated results from the CARTITUDE-1 trial, which previously showed that cilacabtagene autoleucel (cilta-cel) demonstrated early, deep, and durable responses in patients...
CAR T-cell

Research Shows Promising Efficacy of bb21217 in Relapsed/Refractory Myeloma

In a phase I trial, the B-cell maturation antigen (BCMA)–targeting chimeric antigen receptor (CAR) T-cell therapy bb21217 demonstrated “encouraging” efficacy in patients with relapsed/refractory...
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