A novel immune-related gene (IRG) classifier demonstrates robust predictive capabilities in diffuse large B cell lymphoma (DLBCL), according to a study published in the Journal of Immunology Research.
To conduct this study, researchers systematically searched for DLBCL gene expression microarray datasets. They assessed immune-related genes (IRGs) and retrieved 318 transcription factor (TF) targets from a cancer database. The constructed the classifier using 18 IRGs.
According to the results, the multi-IRG classifier showed what the researchers described as “powerful predictive ability.” They observed that patients with a high-risk classifier score had poor survival. Based on the AUC for three- and five-year survival, the classifier exhibited better predictive power than clinical data, the researchers noted.
“Our study describes a novel prognostic IRG classifier with strong predictive power in DLBCL,” wrote the researchers. “Our findings provide valuable guidance for further analysis of DLBCL pathogenesis and clinical treatment.”