Brachial Artery Flow-Mediated Dilation in Patients with Sickle Cell Disease

A study examined the correlation between endothelial dysfunction dictated by brachial artery flow-mediated dilation (FMD), biomarkers of renal dysfunction, and biomarkers of disease severity in patients with sickle cell disease (SCD) without symptoms of renal disease. Patients with SCD, compared with healthy controls, had a significantly lower median FMD (3.44 vs. 5.35). FMD was negatively correlated with cystatin C levels and renal artery resistivity index in patients with SCD. Patients with SCD with FMD <5.35 had significantly higher cystatin C levels.

 

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