Analyzing Primary DLBCL of the Urinary Tract

A study identified factors associated with poor prognostic factors urinary tract (UT) diffuse large B-cell lymphoma (UT-DLBCL). The study appeared in Frontiers in Oncology.

Researchers obtained data from the Surveillance, Epidemiology, and End Results (SEER) database for the data of 489 patients diagnosed with UT-DLBCL (median age, 69) between 1975 and 2016. Data were collated on demographic tumor stage and therapeutic strategies, such as surgical resection, radiation therapy, and chemotherapy. They used Kaplan-Meier curves to assess the impact of these factors on survival outcomes, including overall survival (OS) and disease-specific survival (DSS).

According to the results, most cases of UT-DLBCL (over 72%) originated from the kidney, followed by the urinary bladder (24.95%). Both surgical resection and chemotherapy can significantly improve OS and DSS, the researchers noted. Elderly patients (aged 75 and older) had the worst survival outcomes. Stage IV DLBCL was observed to be a poor prognostic factor.

“To the best of our knowledge, this is the largest population-based study of UT-DLBCL. Advanced age, male gender, lack of surgical resection or chemotherapy, and stage IV DLBCL were poor prognostic factors,” the research team concluded.