Assessing the Clinicopathological Spectrum of DLBCL

A study aimed to assess the clinicopathological characteristics of diffuse large B-cell lymphoma (DLBCL) among affected individuals in Pakistan. The findings were published in BMC Research Notes.

The investigators evaluated patients with DLBCL aged a mean of 50 years. According to the results, the primary DLBCL site was lymph node in around 72% patients, out of which over a quarter had B symptoms and approximately 14% patients had stage IV disease. The study found that patients had primary extra nodal involvement, four patients (3%) had B symptoms and three (2%) had stage IV disease. The researchers noted that nodal sites involved in primary extra nodal DLBCL were gastrointestinal tract (GIT; 49% of patients), tonsils (15%), spine (10%), soft tissue swelling (8%), parotid gland (5%), thyroid (5%), central nervous system (3%), breast (3%), and bone marrow (3%).

“Our study revealed increased percentage of patients with nodal DLBCL in stage IV and with B symptoms,” the researchers wrote. They added that, “Few patients with primary extra nodal DLBCL had B symptoms and stage IV disease at presentation. GIT was the most common site of involvement in primary extra nodal DLBCL.”