Examining the Grey-Zone Between DLBCL Lymphoma and Classical Hodgkin Lymphoma

There exists a grey-zone in lymphoma, which makes the diagnosis between classical Hodgkin lymphoma and diffuse large B-cell lymphoma (DLBCL) hard to discern, according to a study published in Pathology Oncology Research.

In this retrospective analysis, researchers assessed nine gray zone lymphoma patients who were diagnosed between 2008 and 2018. The histological diagnoses were often time challenging, the researchers noted, and they asked for a revision in three cases due to the unusual clinical behavior, whereas in other three cases only the relapse of the disease proved to be grey-zone lymphoma.

“As a rare disease, grey-zone lymphoma has no existing diagnostic criteria or guidelines for its standard of care, which makes the everyday practice rather challenging for the clinicians and emphasize the importance of unique decision making in every case and the repeated consultation between the pathologist and hematologist,” the authors concluded.