Assessing Characteristics and Prognosis of Synchronous Multiple Primary Lung Cancer Following Surgery

By Robert Dillard - Last Updated: February 22, 2021

Both the synchronous multiple primary lung cancer (sMPLC) rate and five-year survival rate in lung cancer are increasing, according to a study published in Cancer Medicine.

Researchers systematically searched PubMed and Embase to identify studies focused on the prognosis of patients with sMPLC after surgery. Overall, they included 52 studies comprising 3,486 participants in the analysis.

According to the results, the proportion of sMPLC in lung cancer was 2.0% (95% confidence interval [CI], 1.6-2.5% with an increasing trend over time, while postoperative mortality was 1.4% (95% CI, 0.5-2.7) with a decreasing trend over time. The five-year survival rate displayed an increasing trend over time at 44.9% (95% CI, 37.4-52.6).

Moreover, the researchers observed that factors such as age, gender, smoking status, forced expiratory volume in one second (FEV1), and lymph node metastasis significantly impacted the long-term prognosis (all P<0.05).

The proportion of sMPLC in lung cancer and five-year survival rate are increasing, while postoperative mortality is decreasing trend over time,” the researchers concluded. “Lobectomy should be preferred, while pneumonectomy should be avoided for sMPLC. Age, gender, FEV1, smoking, tumor size, surgical methods, and lymph node status are prognostic factors for sMPLC.” However, the researchers noted, “Considering the heterogeneity and publication bias, these findings should be treated with caution.”