A study which appeared in Annals of Palliative Medicine aimed to evaluate the prognostic significance of the advanced lung cancer inflammation index (ALI), prognostic nutritional index (PNI), and systemic immune-inflammation index (SII) in diffuse large B-cell lymphoma (DLBCL).
This study consisted of 117 patients with newly diagnosed DLBCL. The researchers utilized receiver operating characteristic curve analysis to discern the optimal cut-off values for the ALI, PNI, and SII to predict survival. The population of interest were stratified into high and low survival groups. Cox regression analysis and the Kaplan-Meier method were then used to assess the prognostic ability of these indexes.
According to the results, the optimal cut-offs for the ALI, PNI, and SII were 31.26, 36.48, and 486.76, respectively. The investigators observed that the ALI had the highest area under the curve score. The high ALI or PNI group had better five-year overall survival (OS) than the low ALI (73% vs. 53%, P<0.001) or PNI (60% vs. 45%, P<0.001) groups, while the low SII group had better five-year OS than the high SII group (67% vs. 62%, P=0.034). While all three parameters were associated with OS in univariate analyses, only the ALI and PNI were independent factors for OS in multivariate analyses. Overall, the study revealed that when patients with DLBCL were classified according to IPI combined with ALI, PNI, or SII, respectively, there were more obvious differences in OS among different types.
“The ALI and PNI may be easily available markers to predict clinical outcomes in DLBCL patients. SII predicted OS only in univariate analysis,” the researchers concluded.