Dustin Samples

Cancer Nursing Today nonprod

A team of researchers and clinicians in British Columbia, Canada, examined the blood plasma metabolome changes in a cohort of pediatric patients with chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). The first author, Tashi Rastogi, presented their results at the 2023 Tandem Transplant &amp; Cellular Therapy Meetings of the ASTCT and CIBMTR.The team used archival samples from the Children&rsquo;s Oncology Group trial #ASCT0031, which enrolled 75 pediatric patients at the onset of cGVHD. Plasma from whole blood samples was analyzed for approximately 142 metabolites via direct-injection mass spectrometry with reverse-phase LC-MS/MS, and the differences between levels in patients with cGVHD (n=38) and non-cGVHD (n=37) were compared.In patients with cGVHD, the research team found &ldquo;significant increases in &alpha;-ketoglutarate and glutamic acid, and close to a significant increase in kynurenine at onset,&rdquo; as well as &ldquo;significant decreases in glutamine,&rdquo; which is generally inversely correlated with glutamic acid.While the team seems to have expected those results, they were more surprised at what they did not observe, stating, &ldquo;secondary metabolome changes, such as an elevation in 18:0SM and decreases in p-hydroxyhippuric acid and acetyl-ornithine were not found in this data.&rdquo;The lack of secondary metabolome changes contradicts findings from a previous study, as does their observation that C8 was &ldquo;significantly increased in this cohort.&rdquo;Rastogi T, Ng B, Johnston L, et al. Validating Alpha-Ketoglutarate As a Biomarker for Chronic Graft-Versus-Host Disease in a Separate Pediatric Cohort. Abstract #348. Presented at the 2023 Tandem Meetings of ASTCT and CIBMTR; February 15-19, 2023; Orlando, FL.

Biomarkers of Chronic Graft-Versus-Host Disease in a Pediatric Cohort

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Increases in α-ketoglutarate, glutamic acid, and kynurenine were observed in patients with chronic GVHD.

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