Lower Lobe Tumors Associated with Higher Mortality in Lung Cancer Patients Treated with Radical Chemoradiotherapy

By Robert Dillard - Last Updated: January 4, 2021

Lower lobe tumors may increase the risk of death in some lung cancer patients, according to the findings of a study published in the journal Tumori.

In this study, the investigators sought to assess the influence of tumor location on survival in lung cancer patients who received radical chemoradiotherapy. They used the Surveillance, Epidemiology, and End Results Program (SEER) database to analyze 14,640 patients with lung cancer who received radical chemoradiotherapy for stage I-III disease. They then retrospectively assessed cases from a cohort of 148 eligible patients diagnosed between December 2013 and December 2019.

According to the results of the study, factors strongly correlated with developing a right lung lobe tumor included female sex, and having adenocarcinoma, or stage III lung cancer. The researchers observed that advanced age at diagnosis was associated with lower lung tumors. For patients who received radical chemoradiotherapy, the 1- and 3-year survival rates were 56.5% and 22.9%, they noted. The results showed that lower lobe origin was closely linked to a shorter overall survival juxtaposed to non-right lower lobe tumors (p<0.001).

“Our results suggest that lower lobe tumor increases mortality risk in patients with lung cancer treated with radical chemoradiotherapy,” the researchers wrote in conclusion.