Robert Dillard

Cancer Nursing Today nonprod

Researchers sought to assess the impact of Hepatitis C virus (HCV) in patients with diffuse large B-cell lymphoma (DLBCL).In this retrospective analysis, published in the Journal of Personalized Medicine, researchers assessed 206 adults with DLBCL from 2011 to 2015. In total, 10.7% were HCV-positive.The results showed that compared to HCV-negative patients, the HCV-positive group had a poor performance status (P = 0.011), lower platelet count (P&nbsp;= 0.029), and higher spleen and liver involvement incidences (liver involvement,&nbsp;P&nbsp;= 0.027; spleen involvement,&nbsp;P&nbsp;= 0.026). This group also received fewer cycles of chemotherapy, significantly due to morbidity and mortality (P&nbsp;= 0.048).The researchers observed that overall survival (OS) was shorter in patients who were HCV-positive compared to HCV-negative (25.3 months vs. not reached, respectively;&nbsp;P&nbsp;= 0.049). The results of multivariate analysis showed that poor performance status (P&lt;0.001), advanced stage (P&lt;0.001), less chemotherapy cycles (P&lt;0.001), and liver toxicity (P&nbsp;= 0.001) contributed to poor OS in DLBCL.&ldquo;Inferior survival of HCV-positive DLBCL was observed and associated with poor performance status, higher numbers of complications, and intolerance of treatment, leading to fewer therapy,&rdquo; the researchers concluded. &ldquo;Therefore, anti-HCV therapy, such as direct-acting antiviral agents, might benefit these patients in the future.&rdquo;

Poor Prognosis of Diffuse Large B-Cell Lymphoma with Hepatitis C Infection

Lymphoma

Researchers sought to assess the impact of Hepatitis C virus (HCV) in patients with diffuse large B-cell lymphoma (DLBCL). In this retrospective analysis, published in the Journal of Personalized Medicine, researchers assessed 206 adults with DLBCL from 2011 to 2015. In total, 10.7% were HCV-positive. The results showed that compared to HCV-negative patients, the HCV-positive [...]

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