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Cancer Nursing Today nonprod

Bispecific antibodies are synthetic proteins that are capable of binding to 2 different sites, either on the same cell or separate ones. They are frequently used in relapsed or refractory multiple myeloma to help T cells bind to cancer cells. Talquetamab is a bispecific antibody that targets CD3 receptors on T cells as well as GPRC5D receptors on malignant plasma cells. A study recently published in the New England Journal of Medicine evaluated the dose-limiting toxic effects, adverse events, and laboratory abnormalities associated with subcutaneous administration of talquetamab.For this study, talquetamab was given in several different subcutaneous dosages to determine the recommended doses for a phase II study. At the cutoff date, 2 target doses were identified for inclusion in phase II: 405 &mu;g/kg weekly (30 patients) and 800 &mu;g/kg every other week (44 patients).In the 74 patients who received these doses in phase I, common adverse events were cytokine release syndrome, skin-related events, and dysgeusia. The breakdown is as follows:<ul>
<li>405 &mu;g/kg weekly (30 patients)
<ul>
<li>77% experienced cytokine release syndrome</li>
<li>67% experienced skin-related events</li>
<li>63% experienced dysgeusia</li>
</ul>
</li>
<li>800 &mu;g/kg every other week (44 patients)
<ul>
<li>80% experienced cytokine release syndrome</li>
<li>70% experienced skin-related events</li>
<li>57% experienced dysgeusia</li>
</ul>
</li>
</ul>Despite the frequency of adverse events, most were mild, with only 1 patient experiencing grade 3 rash in the 800 &mu;g/kg every other week group. For those in either group experiencing cytokine release syndrome, only 1 patient had higher than a grade 1/2 event.Response rates were good in both groups, with 70% achieving response at 11.7 months median follow-up for those receiving 405 &mu;g/kg weekly and 64% achieving response at 4.2 months median follow-up for those receiving 800 &mu;g/kg every other week.&ldquo;Talquetamab induced a substantial response among patients with heavily pretreated relapsed or refractory multiple myeloma,&rdquo; the authors concluded. &ldquo;Cytokine release syndrome, skin-related events, and dysgeusia were common with talquetamab treatment but were primarily low-grade.&rdquo;<h3>Reference</h3><a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2204591" target="_blank" rel="noopener">Talquetamab, a T-cell&ndash;redirecting GPRC5D bispecific antibody for multiple myeloma</a>

Talquetamab Performs Well in NEJM Study of Adverse Events and Responses

Multiple Myeloma

Only 2 patients experienced adverse events higher than grade 1 or 2, and response rates were high. 

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