Kerri Fitzgerald

Cancer Nursing Today nonprod

A study published in Blood Advances observed a high risk of recurrent thrombotic events in patients with myeloproliferative neoplasms (MPN) with a history of venous thromboembolism (VTE), even among those who received long-term oral anticoagulant treatment.Researchers conducted a systematic review and meta-analysis of Medline, Embase, the Cochrane Central Register of Controlled Trials, Web of Science conference proceedings,&nbsp;ClinicalTrials.gov, and the World Health Organization International Clinical Trials Registry Platform to identify randomized trials and observational studies evaluating anticoagulant and/or antiplatelet therapy, with or without cytoreduction, in patients with MPN and a history of VTE.No randomized trials were identified; 10 observational studies involving 1,295 patients with MPN were included in the final analysis. Median duration of follow-up among the studies ranged from 2.1 to 10 years. The median age of study participants ranged from 47 to 75 years, and 57% of the overall study population was female. Essential thrombocytopenia was the most prevalent type of MPN (54%), followed by polycythemia vera (37%).&nbsp;Among the full cohort, 87% (n=1,121) had a history of any thrombosis, while 13% did not have a history of thrombosis (n=174).A total of 623 patients received antiplatelet therapy, most often low-dose aspirin (80 mg). Vitamin K antagonists (VKA) were the most common oral anticoagulant treatment (n=467).Overall, 23% of patients had an arterial or recurrent venous thrombotic event during follow-up. Recurrence risk was lowest for patients receiving oral anticoagulation plus cytoreduction (16%). In 746 analyzed patients, the risk of recurrent VTE ranged up to 33% (median, 13%) and was low in 63 patients treated with direct oral anticoagulants plus cytoreduction (3.2%). All types of antithrombotic treatments were associated with a lower risk of recurrent VTE when combined with cytoreduction.Most studies had a high risk of bias, whereas clinical and statistical heterogeneity led to inconsistent and imprecise findings. &ldquo;Our data suggest that a combination of anticoagulation and cytoreduction may provide the lowest recurrence risk,&rdquo; the researchers concluded.

Antithrombotic Treatment of VTE in Patients with MPN

A study published in Blood Advances observed a high risk of recurrent thrombotic events in patients with myeloproliferative neoplasms (MPN) with a history of venous thromboembolism (VTE), even among those who received long-term oral anticoagulant treatment. Researchers conducted a systematic review and meta-analysis of Medline, Embase, the Cochrane Central Register of Controlled Trials, Web of [...]

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