Cecilia Brown

Cancer Nursing Today nonprod

The cumulative incidence of graft-versus-host disease (GVHD) was higher in patients who received a low CD3-positive T-cell dose during peripheral blood stem-cell product allogeneic transplantation than in those who received a higher dose of CD3-positive cells, according to research presented at the Tenth Annual Meeting of the Society of Hematologic Oncology (SOHO).&ldquo;The outcome of allogeneic [hematopoietic stem-cell transplantation] relies on both disease-related factors and transplant-related factors, including the conditioning regimen and immunotherapy exploiting the graft-versus-tumor effect,&rdquo; the study&rsquo;s authors wrote. &ldquo;CD3+ T-cells are the main player in the [graft-versus-tumor] process, but an increased dose of these cells results in an increased risk of acute [GVHD]. We aimed to study whether the T-cell dose of allogeneic peripheral blood stem-cell product influences transplantation outcomes in our patient population.&rdquo;Rawan Mustafa, MD, of the King Hussein Cancer Center in Amman, Jordan, and colleagues conducted the study and presented its results at the SOHO meeting.The researchers performed a retrospective chart review of adults diagnosed with acute myeloid leukemia, acute lymphoblastic leukemia, or myelodysplastic syndrome who underwent mismatched peripheral blood stem-cell product allogeneic transplantation. The study included 35 patients who received transplants between January 2010 and December 2020 from haploidentical donors, single-antigen mismatched related donors, or 2-allele mismatched related donors. Patients were grouped by their dose of CD3-positive T-cells, low (n=18) or high (n=17).The mean CD3-positive T-cell dose was 13.7&times;107/kg (range, 2.8-19.7) in the low-dose CD3 group, and the mean dose was 29.7&times;107/kg (range, 19.8-93.1) in the high-dose CD3 group.The cumulative incidences of acute GVHD and chronic GVHD were higher in the low-dose CD3 group (60% and 64%, respectively) than in the high-dose CD3 group (40% and 35%, respectively).However, the 1-year and 2-year overall survival (OS) rates were higher in the low-dose CD3 group (66.7% and 66.7%, respectively) than in the high-dose CD3 group (52.9% and 33.1%, respectively). For the entire cohort, the 1-year OS was 60.9%, while the 2-year OS was 49.6%.&ldquo;Although the study showed a trend toward better OS in the low CD3+ dose group, the difference was not statistically significant,&rdquo; Dr. Mustafa and colleagues concluded.Mustafa R, Al-Rimawi D, Sarhan D, et al. Impact of T-cell dose on outcome of T cell&ndash;replete HLA-mismatched allogeneic peripheral blood stem cell transplantation. Poster CT-098. Presented at the Tenth Annual Meeting of the Society of Hematologic Oncology; September 28-October 1, 2022; Houston, TX.

Higher Incidence of GVHD With Low CD3 Dose During Transplant

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The cumulative incidence of graft-versus-host disease was higher in patients who received a low CD3-positive T-cell dose during allogeneic transplantation.

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