Patrick Daly

Cancer Nursing Today nonprod

In a multicenter study, researchers sought to validate the International Chronic Ocular Graft-Versus-Host Disease Consensus Group (ICCGVHD) diagnostic criteria with the 2014 National Institutes of Health (NIH 2014) criteria for <a href="https://cancernursingtoday.com/post/describing-severe-and-non-severe-chronic-ocular-gvhd">chronic ocular graft-versus-host disease</a> (GVHD) as a standard. In their report, published in <a href="https://www.sciencedirect.com/science/article/abs/pii/S1542012422000842">The Ocular Surface</a>, the authors stated that the ICCGVHD score (0-11) showed good sensitivity, specificity, predictive value, and correlation relative to the NIH 2014 eye score (0-4).Between 2013 and 2019, this study enrolled a prospective observational cohort of 233 patients with or without chronic ocular GVHD in the presence or absence of systemic GVHD. Researchers evaluated all participants for the 4 clinical parameters of the ICCGVHD.<h3>ICCGVHD Score Validated Against 2014 NIH Criteria</h3>According to the authors, the ICCGVHD score and NIH 2014 eye score had relatively high relation (r=0.708; 95% CI, 0.637-0.767; P&lt;.001). ICCGVHD with a cutoff value of 6 had a sensitivity of 94.3% (95% CI, 89.6-98.1) and a specificity of 71.7% (95% CI, 63.0-79.5) in detecting individuals who met NIH 2014 criteria. Additionally, the positive predictive value was 77.1% (95% CI, 71.1-82.1), and the negative predictive value was 87.0% (95% CI, 81.6-92.5).In the 171 patients with systemic GVHD, ICCGVHD had a sensitivity and specificity of 94.2% and 67.2%, respectively and an area under the receiver operating characteristic curve (AUC) of 0.903 (95% CI, 0.859-0.948). In the 62 patients without systemic GVHD, the sensitivity and specificity were 100% and 76.7%, respectively, and the AUC was 0.891 (95% CI, 0.673-1.000).Ultimately, the researchers suggested that &ldquo;ICCGVHD scores &ge;6 can be useful to diagnose ocular GVHD with or without systemic GVHD for clinical research.&rdquo;Browse More <a href="https://cancernursingtoday.com/category/gvhd">Recent Research and Expert Opinions on GVHD</a>

Validating the International Chronic Ocular GVHD Consensus Group Diagnostic Criteria

GVHD

In a multicenter study, ICCGVHD score showed good sensitivity, specificity, predictive value, and correlation relative to the 2014 NIH ocular GVHD criteria.

Validating the ICCGVHD Diagnostic Criteria for Ocular GVHD

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