Validating the International Chronic Ocular GVHD Consensus Group Diagnostic Criteria

By Patrick Daly - Last Updated: October 14, 2022

In a multicenter study, researchers sought to validate the International Chronic Ocular Graft-Versus-Host Disease Consensus Group (ICCGVHD) diagnostic criteria with the 2014 National Institutes of Health (NIH 2014) criteria for chronic ocular graft-versus-host disease (GVHD) as a standard. In their report, published in The Ocular Surface, the authors stated that the ICCGVHD score (0-11) showed good sensitivity, specificity, predictive value, and correlation relative to the NIH 2014 eye score (0-4).

Between 2013 and 2019, this study enrolled a prospective observational cohort of 233 patients with or without chronic ocular GVHD in the presence or absence of systemic GVHD. Researchers evaluated all participants for the 4 clinical parameters of the ICCGVHD.

ICCGVHD Score Validated Against 2014 NIH Criteria

According to the authors, the ICCGVHD score and NIH 2014 eye score had relatively high relation (r=0.708; 95% CI, 0.637-0.767; P<.001). ICCGVHD with a cutoff value of 6 had a sensitivity of 94.3% (95% CI, 89.6-98.1) and a specificity of 71.7% (95% CI, 63.0-79.5) in detecting individuals who met NIH 2014 criteria. Additionally, the positive predictive value was 77.1% (95% CI, 71.1-82.1), and the negative predictive value was 87.0% (95% CI, 81.6-92.5).

In the 171 patients with systemic GVHD, ICCGVHD had a sensitivity and specificity of 94.2% and 67.2%, respectively and an area under the receiver operating characteristic curve (AUC) of 0.903 (95% CI, 0.859-0.948). In the 62 patients without systemic GVHD, the sensitivity and specificity were 100% and 76.7%, respectively, and the AUC was 0.891 (95% CI, 0.673-1.000).

Ultimately, the researchers suggested that “ICCGVHD scores ≥6 can be useful to diagnose ocular GVHD with or without systemic GVHD for clinical research.”

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