Toxicity- and disease-related adverse outcomes can affect the quality of life in this high-exposure population. Non-Hispanic Black and Hispanic patients reported worse mental health and poorer sleep than their non-Hispanic White peers. Half of all patients in a synthesized analysis developed infections, and a quarter developed grade III/IV infections. Survey respondents described transportation, information, and scheduling barriers to treatment. With many new targeted drugs available, nurses are under pressure to keep up with administration and toxicity profiles. Nurses at the Huntsman Cancer Institute believe their algorithm successfully predicts PJP and decreases CD4 monitoring costs. Myelosuppression, bone disease, and acute renal failure are discussed in this review, and treatment options are provided. Discussing results from ASH, Cindy Chmielewski from The Patient Story spoke with Drs. Caitlin Costello and Sagar Lonial. It may be possible to eliminate the monitoring period after subcutaneous daratumumab and increase chair availability. The new bispecific antibody boasted an overall response rate of more than 60 percent and has received accelerated approval. Recognizing and managing distress, fatigue, and sexual dysfunction in patients with MM can be difficult. Nurses should assess patients for bone pain and mobility at each encounter and should consider implementing an activity plan. Interprofessional team-based care is the standard for patients undergoing HSCT. But who belongs on the team? Results of the CASTOR trial show promise for three-drug regimen, including reduction in risk of death. Janssen’s Tecvayli has received accelerated approval, while Pfizer’s elranatamab has been designated a breakthrough ... Isatuximab plus carfilzomib and dexamethasone led to a higher MRD negativity rate and more complete responses in MM. This marks the first time a study identified epidemiological and clinical characteristics of SMM in a general population. Researchers evaluated real-world data on DVd for treatment of patients with relapsed or refractory multiple myeloma. Both are malignancies associated with significant immunoparesis. Fabio Efficace, PhD, and a team of researchers investigated IMWG frailty scoring in patients with previously treated disease.