Hepatic veno-occlusive/sinusoidal obstruction syndrome (VOD/SOD) is a serious complication of hematopoietic stem cell transplantation (HSCT) caused by toxicity that results in obstruction of small veins in the liver. It can occur in 10-20% of patients undergoing HSCT, and certain high-risk populations have even higher incidence. Mortality outcomes have improved over the past few years. However, as many as 30-60% of patients who develop hepatic VOD/SOD will experience severe morbidity including multiorgan dysfunction or failure. ...
Myelodysplastic Syndrome
Explore the newest developments in clinical research and treatment for myelodysplastic syndromes (MDS). Cancer Nursing Today has the latest clinical findings and perspectives on personalized risk prediction models for MDS, genetic mutations related to MDS progression, donor lymphocyte infusions, and more. From clinical trials and screening techniques to the latest treatments, learn how MDS care is evolving.
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Survival rates for myelodysplastic syndromes (MDS) varies widely – from months to decades – highlighting the need for ...
For post-transplant disease control in patients with myelodysplastic syndromes (MDS), donor lymphocyte infusion (DLI) has ...
Compared with placebo, treatment with CC-486, the oral formulation of the hypomethylating agent (HMA) azacitidine ...
Results from a randomized, proof-of-concept, phase II study demonstrated promising overall survival (OS), event-free survival ...
In a prospective multicenter study, older patients with myelodysplastic syndromes (MDS) who underwent reduced-intensity ...
Treatment with enasidenib, a small molecule inhibitor of mutant IDH2, showed promising clinical activity in patients with ...
A study published in Hematology, Transfusion & Cell Therapy found that FLT3, NPM1, IDH1, and IDH2 gene mutations may ...
A study published in Cancer Causes & Control observed that smoking, history of autoimmune disease, and benzene exposure ...
The use of poly (ADP-ribose) polymerase (PARP) inhibitors increased the risk of developing myelodysplastic syndromes (MDS) ...
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