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Sickle Cell Disease

Women With SCD Are at High Risk of Pregnancy Complications

In a retrospective study presented at the 2021 ASH Annual Meeting, researchers described the outcomes for pregnant women with SCD, who are considered at...

ATLAS-INH: Fitusiran Reduces Bleeding Rates in Hemophilia A and B With Inhibitors

According to the results of the phase III ATLAS-INH study, administration of prophylactic fitusiran significantly reduced annualized bleeding rates (ABRs) among patients with hemophilia...

Mitapivat Produces Durable Hemoglobin Responses in Patients With Pyruvate Kinase Deficiency

Based on analysis of data from the ACTIVATE and ACTIVATE-T studies and their associated long-term extension (LTE) phases, mitapivat (AG-348) appeared to significantly improve...

bb1111 Gene Therapy Improves Quality of Life for Sickle Cell Patients

According to findings presented at the 2021 ASH Annual Meeting, the gene therapy bb111 demonstrated clinically meaningful improvements in quality of life (QOL) for...

COVID-19 Vaccination Does Not Increase Risk of Deep Vein Thrombosis

Researchers found no increased risk for acute deep vein thrombosis (DVT) post-vaccination for any of the approved COVID-19 vaccines in the United States, according...

Etavopivat Improves Anemia and Hemolysis in Sickle Cell Disease

According to results of a multiple-dose studies at the 2021 ASH Annual Meeting, treatment with etavopivat, a small molecule activator of erythrocyte pyruvate kinase,...

Factors That Predict Quality of Life in Pediatric Patients With Sickle Cell Disease

Sickle cell disease (SCD) impacts health-related quality of life (HRQOL) through many physical and emotional pathways, including acute and chronic pain, sleep disruption, and...
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